Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43.

@article{Salameh2010CyclicMS,
  title={Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43.},
  author={Aida Salameh and Anne Wustmann and Sebastian Karl and Katja Blanke and Daniel Apel and Diana Rojas-G{\'o}mez and Heike Franke and Friedrich W. Mohr and Jan Janousek and Stefan Dhein},
  journal={Circulation research},
  year={2010},
  volume={106 10},
  pages={1592-602}
}
RATIONALE Cyclic mechanical stretch (CMS) is an important physiological and pathological factor in the heart. OBJECTIVE We examined whether CMS can affect localization of gap junctions with regard to the cell axis. METHODS AND RESULTS Neonatal rat cardiomyocytes were cultured (7 days) on flexible 6-well plates. Thereafter, cells were kept static or stimulated with CMS (1 Hz; 0, 10, 20% elongation) for 0, 24, or 48 hours (with or without 10 micromol/L PD98059, 5 micromol/L BIM I… CONTINUE READING

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Signal transduction and transcriptional control of cardiac connexin 43 up - regulation after α 1Adrenoceptor stimulation

  • A Salameh, K Krautblatter, +4 authors D Pfeiffer
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