Cyclic mechanical strain regulates the development of engineered smooth muscle tissue

@article{Kim1999CyclicMS,
  title={Cyclic mechanical strain regulates the development of engineered smooth muscle tissue},
  author={Byung-Soo Kim and Janeta Nikolovski and Jeffrey Bonadio and David J Mooney},
  journal={Nature Biotechnology},
  year={1999},
  volume={17},
  pages={979-983}
}
We show that the appropriate combinations of mechanical stimuli and polymeric scaffolds can enhance the mechanical properties of engineered tissues. The mechanical properties of tissues engineered from cells and polymer scaffolds are significantly lower than the native tissues they replace. We hypothesized that application of mechanical stimuli to engineered tissues would alter their mechanical properties. Smooth muscle tissue was engineered on two different polymeric scaffolds and subjected to… CONTINUE READING

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Expression of brush border enzymes and formation of basement membrane from transplanted intestinal epithelial organoid units using biodegradable tubular scaffolds

R. S. Choi, B. S. Kim, D. J. Mooney, J. P. Vacanti
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