Cyclic loading inhibits expression of MMP-3 but not MMP-1 in an in vitro rabbit flexor tendon model.

@article{Asundi2008CyclicLI,
  title={Cyclic loading inhibits expression of MMP-3 but not MMP-1 in an in vitro rabbit flexor tendon model.},
  author={Krishna R. Asundi and David M. Rempel},
  journal={Clinical biomechanics},
  year={2008},
  volume={23 1},
  pages={
          117-21
        }
}
BACKGROUND Gene expression analysis is useful for assessing cellular behavior and may improve our understanding of the initial cellular response to mechanical load leading to tendon degeneration. This study assessed gene expression of MMP-1 and MMP-3, genes associated with matrix degradation, in tendons exposed to cyclic loads within physiologic range. METHODS Six flexor tendons from each of ten New Zealand White rabbits were harvested and randomly assigned to one of the following six groups… CONTINUE READING
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Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation.

  • Scandinavian journal of medicine & science in sports
  • 2015
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