Cyclic hydrostatic pressure stimulates enhanced bone development in the foetal chick femur in vitro.

@article{Henstock2013CyclicHP,
  title={Cyclic hydrostatic pressure stimulates enhanced bone development in the foetal chick femur in vitro.},
  author={James R. Henstock and Michael Rotherham and J. Bruce Ralphin Rose and Alicia J El Haj},
  journal={Bone},
  year={2013},
  volume={53 2},
  pages={468-77}
}
Mechanical loading of bone and cartilage in vivo results in the generation of cyclic hydrostatic forces as bone compression is transduced to fluid pressure in the canalicular network and the joint synovium. It has therefore been suggested that hydrostatic pressure is an important stimulus by which osteochondral cells and their progenitors sense and respond to mechanical loading in vivo. In this study, hydrostatic pressure regimes of 0-279kPa at 0.005-2Hz were applied to organotypically cultured… CONTINUE READING

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