Cyclic guanosine monophosphate in the regulation of the cell function.

  title={Cyclic guanosine monophosphate in the regulation of the cell function.},
  author={Małgorzata Zbrojkiewicz and Leszek Śliwiński},
  journal={Postepy higieny i medycyny doswiadczalnej},
  volume={70 0},
Intracellular concentration of cGMP depends on the activity of guanylate cyclase, responsible for its synthesis, on the activity of cyclic nucleotide degrading enzymes - phosphodiesterases (PDEs). There are two forms of guanylate cyclase: the membrane-bound cyclase and the soluble form. The physiological activators of the membrane guanylate cyclase are natriuretic peptides (NPs), and of the cytosolic guanylate cyclase - nitric oxide (NO) and carbon monoxide (CO). Intracellular cGMP signaling… CONTINUE READING
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