Cyclic fluctuations in the cardiac performance of the isolated Langendorff-perfused mouse heart: pyruvate abolishes the fluctuations and has an anti-ischaemic effect.

@article{Wang2002CyclicFI,
  title={Cyclic fluctuations in the cardiac performance of the isolated Langendorff-perfused mouse heart: pyruvate abolishes the fluctuations and has an anti-ischaemic effect.},
  author={Q D Wang and Shinichi Tokuno and Guro Valen and P. O. Sj{\"o}quist and Peter Thor{\'e}n},
  journal={Acta physiologica Scandinavica},
  year={2002},
  volume={175 4},
  pages={279-87}
}
During the development of a Langendorff preparation of isolated mouse hearts, hitherto undescribed cyclic fluctuations in left ventricular pressure and coronary flow were independently observed in three laboratories. Isolated mouse hearts were perfused with crystalloid glucose-containing Krebs-Hensleit buffer in a constant pressure model, and left ventricular pressures were measured via an intraventricular balloon catheter. After acquiring technical skill in preparing the mouse hearts, the… CONTINUE READING