Cyclic dipeptides exhibit potency for scavenging radicals.

  title={Cyclic dipeptides exhibit potency for scavenging radicals.},
  author={Tadashi Furukawa and Takashi Akutagawa and Hitomi Funatani and Toshikazu Uchida and Yoshihiro Hotta and Masatake Niwa and Yoshiaki Takaya},
  journal={Bioorganic & medicinal chemistry},
  volume={20 6},
Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against ·OH and O(2)(·-) was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against ·OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O(2)(·-). 


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