Cyclic dinucleotides modulate induced type I IFN responses in innate immune cells by degradation of STING.

@article{Rueckert2017CyclicDM,
  title={Cyclic dinucleotides modulate induced type I IFN responses in innate immune cells by degradation of STING.},
  author={Christine Rueckert and Ulfert Rand and Urmi Roy and Bahram Kasmapour and Till Strowig and Carlos Alberto Guzm{\'a}n},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2017},
  volume={31 7},
  pages={
          3107-3115
        }
}
The cyclic dinucleotides, GMP-AMP (cGAMP) and c-di-AMP [bis-(3',5')-cyclic dimeric AMP], are potent type I IFN inducers via STING-TBK1-IRF3 cascade. They are promising adjuvants that promote antigen-specific humoral and cellular immune responses in different preclinical models; however, an optimal outcome of vaccination depends on a balanced immune activation. Here, we characterize the process of IFN-β induction by c-di-AMP and cGAMP in an in vitro model on the basis of primary mouse dendritic… CONTINUE READING

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