Cyclic di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in Staphylococcus aureus but dispensable for viability in anaerobic conditions

@inproceedings{Zeden2018CyclicDM,
  title={Cyclic di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in Staphylococcus aureus but dispensable for viability in anaerobic conditions},
  author={Merve S. Zeden and Christopher F Schuster and Lisa N. Bowman and Qiyun Zhong and H. David Williams and Angelika Gr{\"u}ndling},
  booktitle={The Journal of biological chemistry},
  year={2018}
}
Cyclic di-adenosine monophosphate (c-di-AMP) is a recently discovered signaling molecule important for the survival of Firmicutes, a large bacterial group that includes notable pathogens such as Staphylococcus aureus However, the exact role of this molecule has not been identified. dacA, the S. aureus gene encoding the diadenylate cyclase enzyme required for c-di-AMP production, cannot be deleted when bacterial cells are grown in rich medium, indicating that c-di-AMP is required for growth in… CONTINUE READING
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