Cyclic di-AMP mediates biofilm formation.

  title={Cyclic di-AMP mediates biofilm formation.},
  author={Xian E Peng and Yang Zhang and Guangchun Bai and Xuedong Zhou and Hui Wu},
  journal={Molecular microbiology},
  volume={99 5},
Cyclic di-AMP (c-di-AMP) is an emerging second messenger in bacteria. It has been shown to play important roles in bacterial fitness and virulence. However, transduction of c-di-AMP signaling in bacteria and the role of c-di-AMP in biofilm formation are not well understood. The level of c-di-AMP is modulated by activity of di-adenylyl cyclase that produces c-di-AMP and phosphodiesterase (PDE) that degrades c-di-AMP. In this study, we determined that increased c-di-AMP levels by deletion of the… CONTINUE READING