Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation.

@article{Croos2006CyclicCM,
  title={Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation.},
  author={J N Amrith De Croos and Satvinda S Dhaliwal and Marc D. Grynpas and Robert M. Pilliar and Rita A Kandel},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2006},
  volume={25 6},
  pages={323-31}
}
Overcoming the limited ability of articular cartilage to self-repair may be possible through tissue engineering. However, bioengineered cartilage formed using current methods does not match the physical properties of native cartilage. In previous studies we demonstrated that mechanical stimulation improved cartilage tissue formation. This study examines the mechanisms by which this occurs. Application of uniaxial, cyclic compression (1 kPa, 1 Hz, 30 min) significantly increased matrix… CONTINUE READING