Cyclic changes in the affinity of protein–DNA interactions drive the progression and regulate the outcome of the Tn10 transposition reaction

@article{Liu2005CyclicCI,
  title={Cyclic changes in the affinity of protein–DNA interactions drive the progression and regulate the outcome of the Tn10 transposition reaction},
  author={Danxu Liu and Paul Crellin and Ronald Chalmers},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={1982 - 1992}
}
The Tn10 transpososome is a DNA processing machine in which two transposon ends, a transposase dimer and the host protein integration host factor (IHF), are united in an asymmetrical complex. The transitions that occur during one transposition cycle are not limited to chemical cleavage events at the transposon ends, but also involve a reorganization of the… CONTINUE READING