Cyclic changes in NMDA receptor activation in hippocampal CA1 neurons after ischemia

@article{Oguro1997CyclicCI,
  title={Cyclic changes in NMDA receptor activation in hippocampal CA1 neurons after ischemia},
  author={Keiji Oguro and Takahiro Miyawaki and Hiroyuki Cho and Hidenori Yokota and N. Kawai},
  journal={Neuroscience Research},
  year={1997},
  volume={29},
  pages={273-281}
}
We studied N-methyl-D-aspartate (NMDA) receptor-mediated synaptic potentials in CA1 pyramidal neurons using hippocampal slices of gerbils after transient forebrain ischemia. In the presence of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and bicuculline, stimulation of Schaffer collateral/commissural fibers induced field excitatory postsynaptic potentials (fEPSP) activated by NMDA receptors. We found that in many slices after ischemia, prolonged low-frequency stimulation (0.1-10 Hz) caused… CONTINUE READING