Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease.

@article{Xia2007CyclicAD,
  title={Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease.},
  author={Jiang Xia and Elin Bergseng and Burkhard Fleckenstein and Matthew Siegel and C Kim and Chaitan Khosla and Ludvig M. Sollid},
  journal={Bioorganic & medicinal chemistry},
  year={2007},
  volume={15 20},
  pages={6565-73}
}
Celiac disease is an immune mediated enteropathy elicited by gluten ingestion. The disorder has a strong association with HLA-DQ2. This HLA molecule is involved in the disease pathogenesis by presenting gluten peptides to T cells. Blocking the peptide-binding site of DQ2 may be a way to treat celiac disease. In this study, two types of peptide analogues, modeled after natural gluten antigens, were studied as DQ2 blockers. (a) Cyclic peptides. Cyclic peptides containing the DQ2-alphaI gliadin… CONTINUE READING
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