Cyclic alkenenitriles: chemoselective oxonitrile cyclizations.


Potassium tert-butoxide triggers the chemoselective cyclization between nitrile anions and remote, enolizable carbonyl groups, despite the acidity difference favoring enolate formation and addition to the nitrile group. Domino deprotonation, cyclization, and dehydration efficiently transform a diverse array of omega-oxonitriles into carbocyclic and… (More)


Cite this paper

@article{Fleming2002CyclicAC, title={Cyclic alkenenitriles: chemoselective oxonitrile cyclizations.}, author={Fraser F Fleming and Lee A Funk and Ramazan Altundaş and Vaqar A. Sharief}, journal={The Journal of organic chemistry}, year={2002}, volume={67 26}, pages={9414-6} }