Cyclic administration of pamidronate in children with severe osteogenesis imperfecta.

@article{Glorieux1998CyclicAO,
  title={Cyclic administration of pamidronate in children with severe osteogenesis imperfecta.},
  author={F. Glorieux and N. Bishop and H. Plotkin and G. Chabot and G. Lanoue and R. Travers},
  journal={The New England journal of medicine},
  year={1998},
  volume={339 14},
  pages={
          947-52
        }
}
BACKGROUND Severe osteogenesis imperfecta is a disorder characterized by osteopenia, frequent fractures, progressive deformity, loss of mobility, and chronic bone pain. There is no effective therapy for the disorder. We assessed the effects of treatment with a bisphosphonate on bone resorption. METHODS In an uncontrolled observational study involving 30 children who were 3 to 16 years old and had severe osteogenesis imperfecta, we administered pamidronate intravenously (mean [+/-SD] dose, 6.8… Expand
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