Cyclic administration of pamidronate in children with severe osteogenesis imperfecta.

@article{Glorieux1998CyclicAO,
  title={Cyclic administration of pamidronate in children with severe osteogenesis imperfecta.},
  author={Francis H Glorieux and N. J. Bishop and Horacio Plotkin and Guillaume Chabot and G Lanoue and Rose Travers},
  journal={The New England journal of medicine},
  year={1998},
  volume={339 14},
  pages={
          947-52
        }
}
BACKGROUND Severe osteogenesis imperfecta is a disorder characterized by osteopenia, frequent fractures, progressive deformity, loss of mobility, and chronic bone pain. There is no effective therapy for the disorder. We assessed the effects of treatment with a bisphosphonate on bone resorption. METHODS In an uncontrolled observational study involving 30 children who were 3 to 16 years old and had severe osteogenesis imperfecta, we administered pamidronate intravenously (mean [+/-SD] dose, 6.8… Expand
Cyclic Pamidronate Therapy in Children with Osteogenesis Imperfecta
TLDR
There was a significant relief of chronic pain and fatigue but no adverse effects in all children using the drug and cyclic pamidronate administration is effective in improving bone mineralization and reducing fracture incidence in childhood osteogenesis imperfecta. Expand
Effect of intravenous pamidronate treatment in children with osteogenesis imperfecta.
TLDR
Bisphosphonate seems to be an effective symptomatic treatment for children with osteogenesis imperfecta irrespective of severity of mutation or clinical phenotype and has a positive effect on fracture rate, BMD, mobility score, wellbeing and pain episode. Expand
Pamidronate Treatment of Children with Moderate-to-Severe Osteogenesis Imperfecta: A Note of Caution
TLDR
Pamidronate with physiotherapy and orthopedic management improved outcomes without delaying fracture healing in 19 (70%) of 27 patients, and should be reserved for severe OI with multiple fractures and/or flattened vertebras. Expand
Beneficial effects of intravenous pamidronate treatment in children with osteogenesis imperfecta under 24 months of age
TLDR
Treatment with intravenous pamidronate is safe, significantly improves lumbar bone mineral density (L-BMD), and reduces fracture rates in young infants with OI while preserving linear growth. Expand
Intravenous pamidronate treatment of children under 36 months of age with osteogenesis imperfecta.
TLDR
The data support that intravenous pamidronate therapy is safe, increases BMD, and reduces fracture rates in very young children with OI and would seem to be the best available treatment for these children. Expand
Cyclic pamidronate infusion for neonatal-onset osteogenesis imperfecta.
TLDR
Patients with neonatal OI can have a favorable outcome when treated with cyclic pamidronate infusions early in life, and all patients showed a rapid increase in bone mineral density over the first 2 years. Expand
Radiological features of bisphosphonate therapy in children with osteogenesis imperfecta.
TLDR
The radiographic features of cyclic pamidronate administration on the growing skeleton in children with OI, a genetic disorder of type-I collagen, are determined and described. Expand
Low-dose intravenous pamidronate treatment in osteogenesis imperfecta.
TLDR
Low-dose cyclical pamidronate infusions markedly increased bone density and decreased bone fracture rate and should be considered as a part of a multi-disciplinary treatment in children with osteogenesis imperfecta. Expand
Pamidronate Treatment of Less Severe Forms of Osteogenesis Imperfecta in Children
TLDR
Pamidronate treatment improves bone quality in children with mild types of OI, improves mobility, reduces fracture frequency and thus improves quality of life and in future is likely to reduce the severity and consequences of adult osteoporosis by improved peak bone mass in these children. Expand
Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta
TLDR
Disodium pamidronate (APD) was given as monthly intravenous infusions to 28 children and adolescents with severe OI or a milder form of the disease, but with spinal compression fractures to find an effective symptomatic treatment. Expand
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