Cyclic adenosine monophosphate signaling in the rat vomeronasal organ: role of an adenylyl cyclase type VI.

@article{Roessler2000CyclicAM,
  title={Cyclic adenosine monophosphate signaling in the rat vomeronasal organ: role of an adenylyl cyclase type VI.},
  author={Patricia Roessler and C Kroner and J{\"u}rgen Krieger and D L{\"o}bel and Heinz Breer and Ingrid Boekhoff},
  journal={Chemical senses},
  year={2000},
  volume={25 3},
  pages={
          313-22
        }
}
The present study indicates that male rat urinary components in female rat vomeronasal organ microvillar preparations not only induce a rapid and transient IP(3) signal, but in addition, the level of cAMP decreases with a delayed and sustained time course. This decrease seems to be a consequence of the preceding activation of the phosphoinositol pathway rather than the result of an enhanced phosphodiesterase activity or an inhibition of adenylyl cyclase (AC) via Galpha(i) or Galpha(o). This… 

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