Cyclic adenosine monophosphate signaling in the rat vomeronasal organ: role of an adenylyl cyclase type VI.

@article{Roessler2000CyclicAM,
  title={Cyclic adenosine monophosphate signaling in the rat vomeronasal organ: role of an adenylyl cyclase type VI.},
  author={Paul Roessler and Christine I Kroner and J{\"u}rgen Krieger and Dietrich L{\"o}bel and Heinz Breer and Ingrid Boekhoff},
  journal={Chemical senses},
  year={2000},
  volume={25 3},
  pages={313-22}
}
The present study indicates that male rat urinary components in female rat vomeronasal organ microvillar preparations not only induce a rapid and transient IP(3) signal, but in addition, the level of cAMP decreases with a delayed and sustained time course. This decrease seems to be a consequence of the preceding activation of the phosphoinositol pathway rather than the result of an enhanced phosphodiesterase activity or an inhibition of adenylyl cyclase (AC) via Galpha(i) or Galpha(o). This… CONTINUE READING

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