Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety.

@article{Beer1972CyclicAM,
  title={Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety.},
  author={Bernard Beer and Mark Chasin and Donald E. Clody and John R. Vogel},
  journal={Science},
  year={1972},
  volume={176 4033},
  pages={428-30}
}
Drugs that reduce anxiety may be mediated by cyclic adenosine monophosphate in the brain because (i) potent anxiety-reducing drugs are also potent inhibitors of brain phosphodiesterase activity; (ii) dibutyryl cyclic adenosine monophosphate has the ability to reduce anxiety; (iii) the methylxanthines show significant anxiety-reducing effects; (iv) theophylline and chlordiazepoxide produce additive anxiety-reducing activity; and (v) there is a significant correlation between the anxiety-reducing… CONTINUE READING