Cyclic adenosine monophosphate and ovarian follicular fluid act synergistically to inhibit mouse oocyte maturation.

@article{Downs1984CyclicAM,
  title={Cyclic adenosine monophosphate and ovarian follicular fluid act synergistically to inhibit mouse oocyte maturation.},
  author={Stephen M Downs and John J. Eppig},
  journal={Endocrinology},
  year={1984},
  volume={114 2},
  pages={418-27}
}
The relationship between cAMP and the capacity of two partially-purified fractions of porcine follicular fluid (PFF) to suppress mouse oocyte maturation was investigated. The fractions used were: 1) a low molecular weight filtrate (less than 10,000) derived from Amicon PM10 filtration of PFF (PM10), and 2) a fraction from Bio-Gel P2 chromatography of the PM10 filtrate (Bio-Gel) that has meiotic inhibitory activity in porcine oocytes. PM10 alone produced a transient inhibition of the maturation… CONTINUE READING

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