Cyclic adenosine 3',5'-monophosphate responsive element binding protein phosphorylation is required but not sufficient for activation of corticotropin-releasing hormone transcription.

@article{Liu2008CyclicA3,
  title={Cyclic adenosine 3',5'-monophosphate responsive element binding protein phosphorylation is required but not sufficient for activation of corticotropin-releasing hormone transcription.},
  author={Ying Liu and Anna Kamitakahara and Alice Joohee Kim and G. Romero Aguilera},
  journal={Endocrinology},
  year={2008},
  volume={149 7},
  pages={3512-20}
}
cAMP is a major regulator of CRH transcription. However, receptors activating CRH neurons (alpha-adrenergic and glutamatergic) do not signal through cAMP, suggesting that calcium phospholipid-dependent signaling synergizes with small elevations of intracellular cAMP. To test this hypothesis, we examined the relationship between activation of CRH transcription, cAMP production, and cAMP response element binding protein (CREB) phosphorylation in neuronal cultures treated with the adenylyl cyclase… CONTINUE READING