Cyclic Stress at mHz Frequencies Aligns Fibroblasts in Direction of Zero Strain

@inproceedings{Faust2011CyclicSA,
  title={Cyclic Stress at mHz Frequencies Aligns Fibroblasts in Direction of Zero Strain},
  author={U. Faust and Nico Hampe and Wolfgang Rubner and Norbert Kirchge\ssner and Sam Safran and Bernd Hoffmann and Rudolf Merkel},
  booktitle={PloS one},
  year={2011}
}
Recognition of external mechanical signals is vital for mammalian cells. Cyclic stretch, e.g. around blood vessels, is one such signal that induces cell reorientation from parallel to almost perpendicular to the direction of stretch. Here, we present quantitative analyses of both, cell and cytoskeletal reorientation of umbilical cord fibroblasts. Cyclic strain of preset amplitudes was applied at mHz frequencies. Elastomeric chambers were specifically designed and characterized to distinguish… CONTINUE READING
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