Cyclic Strain Stimulates Early Growth Response Gene Product 1–Mediated Expression of Membrane Type 1 Matrix Metalloproteinase in Endothelium

@article{Yamaguchi2002CyclicSS,
  title={Cyclic Strain Stimulates Early Growth Response Gene Product 1–Mediated Expression of Membrane Type 1 Matrix Metalloproteinase in Endothelium},
  author={Seiichi Yamaguchi and Miho Yamaguchi and Eiji Yatsuyanagi and Sang-Soeb Yun and Nobuyuki Nakajima and Joseph A. Madri and Bauer E. Sumpio},
  journal={Laboratory Investigation},
  year={2002},
  volume={82},
  pages={949-956}
}
Matrix metalloproteinases (MMPs) are hypothesized to be involved in the processes of endothelial cell (EC) migration and matrix remodeling during angiogenesis. Although hemodynamic forces (such as blood pressure, wall tension, and shear stress) are considered to be strong stimuli for angiogenesis, the role of hemodynamic forces on the regulation of MMPs including membrane type 1 matrix metalloproteinase (MT1-MMP) has not been fully elucidated. To study this, rat microvascular EC were exposed to… CONTINUE READING
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