Cyclic RGD peptide analogues as antiplatelet antithrombotics.
@article{Barker1992CyclicRP,
title={Cyclic RGD peptide analogues as antiplatelet antithrombotics.},
author={P. Barker and S. Bullens and S. Bunting and D. Burdick and K. Chan and T. Deisher and C. Eigenbrot and T. Gadek and R. Gantzos and M. Lipari},
journal={Journal of medicinal chemistry},
year={1992},
volume={35 11},
pages={
2040-8
}
}Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation. GPIIbIIIa/Fg binding inhibitors are potentially suitable for acute use during and after thrombolytic therapy as antithrombotic agents. Incorporation of the tripeptide sequence Arg-Gly-Asp (RGD), a common structural element of many integrin ligands, into cyclic peptides produced a series of peptides of the general structure BrAc-(AA1)-RGD-Cys-OH… CONTINUE READING
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