Cyclic RGD peptide analogues as antiplatelet antithrombotics.
@article{Barker1992CyclicRP, title={Cyclic RGD peptide analogues as antiplatelet antithrombotics.}, author={Peter L. Barker and Sherron L. Bullens and Stuart Bunting and Daniel J Burdick and K S Chan and Theresa A. Deisher and Charles Eigenbrot and Thomas R. Gadek and Robin D. Gantzos and Michael T. Lipari}, journal={Journal of medicinal chemistry}, year={1992}, volume={35 11}, pages={ 2040-8 } }
Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation. GPIIbIIIa/Fg binding inhibitors are potentially suitable for acute use during and after thrombolytic therapy as antithrombotic agents. Incorporation of the tripeptide sequence Arg-Gly-Asp (RGD), a common structural element of many integrin ligands, into cyclic peptides produced a series of peptides of the general structure BrAc-(AA1)-RGD-Cys-OH…
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