Cyclic Peptides for Protein-Protein Interaction Targets: Applications to Human Disease.

Abstract

Protein-protein interactions (PPIs) represent a significant portion of functionally relevant biological interactions, and therefore potential therapeutic targets. Small molecules were traditionally used to target PPIs. However, many PPI surfaces lack binding pockets due to their large and flat structures. Antibodies can also be used to modulate PPIs, but… (More)
DOI: 10.1615/CritRevEukaryotGeneExpr.2016016525

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