Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction

@article{Dewan2012CyclicPI,
  title={Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction},
  author={Varun Dewan and T. Liu and Kuan-Ming Chen and Ziqing Qian and Yong Xiao and L. Kleiman and K. Mahasenan and C. Li and H. Matsuo and D. Pei and K. Musier-Forsyth},
  journal={ACS Chemical Biology},
  year={2012},
  volume={7},
  pages={761 - 769}
}
The human immunodeficiency virus type 1 (HIV-1) capsid protein (CA) plays a critical role in the viral life cycle. The C-terminal domain (CTD) of CA binds to human lysyl-tRNA synthetase (hLysRS), and this interaction facilitates packaging of host cell tRNALys,3, which serves as the primer for reverse transcription. Here, we report the library synthesis, high-throughput screening, and identification of cyclic peptides (CPs) that bind HIV-1 CA. Scrambling or single-residue changes of the selected… Expand
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