Cyclic Peptide Containing Hydrophobic and Positively Charged Residues as a Drug Delivery System for Curcumin.

@article{Shirazi2016CyclicPC,
  title={Cyclic Peptide Containing Hydrophobic and Positively Charged Residues as a Drug Delivery System for Curcumin.},
  author={Amir Nasrolahi Shirazi and Naglaa Salem El-Sayed and Rakesh Kumar Tiwari and Kathy Tavakoli and Keykavous Parang},
  journal={Current drug delivery},
  year={2016},
  volume={13 3},
  pages={409-17}
}
Due to the low water solubility and hydrophobic nature of curcumin, an efficient cellular uptake is critical for its biological activity. We have previously developed a number of homochiral L-cyclic peptides containing arginine and tryptophan as cell-penetrating peptides. Among the synthesized peptides, [WR]5 containing five arginine and five tryptophan residues was found to be the most efficient one. Here, we have compared the application of [WR]5 to improve the intracellular uptake of… CONTINUE READING