Cyclic GMP regulation of myosin phosphatase: a new piece for the puzzle?

@article{Somlyo2007CyclicGR,
  title={Cyclic GMP regulation of myosin phosphatase: a new piece for the puzzle?},
  author={A. Somlyo},
  journal={Circulation research},
  year={2007},
  volume={101 7},
  pages={
          645-7
        }
}
  • A. Somlyo
  • Published 2007
  • Biology, Medicine
  • Circulation research
  • See related article, pages 712–722 The contractile state of smooth muscle (SM) reflects the ratio of activities of myosin light-chain kinase (MLCK) and myosin light chain phosphatase (MLCP), which determines the extent of regulatory light chain (RLC) phosphorylation and actin-activated myosin II activity and can be changed by modulating the activities of the calcium-calmodulin–dependent MLCK or of MLCP. Agonists through G protein–coupled receptors, which activate the small G protein RhoA and… CONTINUE READING
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    References

    SHOWING 1-10 OF 21 REFERENCES
    Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase.
    • 160
    • PDF
    Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphate.
    • 162
    Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo
    • 569
    • PDF
    Role of Myosin Phosphatase Isoforms in cGMP-mediated Smooth Muscle Relaxation*
    • 109
    • PDF