Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury.

@article{Pifarr2010CyclicGP,
  title={Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury.},
  author={Paula Pifarr{\'e} and Judith Prado and Mercedes Giralt and Amalia Molinero and Juan Hidalgo and Agustina Garc{\'i}a},
  journal={Journal of neurochemistry},
  year={2010},
  volume={112 3},
  pages={807-17}
}
Recent evidence obtained in cultured glial cells indicates that cGMP-mediated pathways regulate cytoskeleton dynamics, glial fibrillary acidic protein expression and motility in astrocytes, as well as inflammatory gene expression in microglia, suggesting a role in the regulation of the glial reactive phenotype. The aim of this work was to examine if cGMP regulates the glial inflammatory response in vivo following CNS damage caused by a focal cryolesion onto the cortex in rats. Results show that… CONTINUE READING

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