• Corpus ID: 2950912

Cyclic GMP-induced activation of potassium currents by sarcoplasmic reticulum Ca2+ pump-dependent mechanism.

@article{Duridanova1995CyclicGA,
  title={Cyclic GMP-induced activation of potassium currents by sarcoplasmic reticulum Ca2+ pump-dependent mechanism.},
  author={Dessislava B. Duridanova and Hristo S Gagov and Georgi V. Petkov and G B Shkodrov and Kiril K. Boev},
  journal={General physiology and biophysics},
  year={1995},
  volume={14 2},
  pages={
          139-51
        }
}
In voltage-clamped single smooth muscle cells from the circular layer of the guinea-pig gastric fundus NO-liberating substance or an analogue of cyclic 3, 5'-guanosine monophosphate (cGMP) increased or decreased the outward K+ current amplitudes depending on the Ca2+ buffering capacity of the intracellular medium. In a high EGTA-containing pipette solution dibutyryl-cGMP or sodium nitroprusside (SNP) attenuated both the fast and the late K+ current components. In pipette solution with lower Ca2… 

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