Cyclic GMP in Vascular Relaxation: Export Is of Similar Importance as Degradation.

@article{Krawutschke2015CyclicGI,
  title={Cyclic GMP in Vascular Relaxation: Export Is of Similar Importance as Degradation.},
  author={Christian Krawutschke and Doris Koesling and Michael Russwurm},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 9},
  pages={2011-9}
}
OBJECTIVE In the vascular system, cyclic GMP (cGMP) in smooth muscle cells plays an important role for blood vessel relaxation. Intracellular concentrations of cGMP are thought to be determined by the action of cGMP-generating guanylyl cyclases (sensitive to nitric oxide or natriuretic peptides) and cGMP-degrading phosphodiesterases (PDE1, PDE3, and PDE5). Because functionally relevant cGMP elevations are not accessible to conventional methods, we applied real-time imaging with a fluorescence… CONTINUE READING
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