Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG

@article{Lei2000CyclicGF,
  title={Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG},
  author={Saobo Lei and Michael F Jackson and Zhengping Jia and John Carling Roder and Donglin Bai and Beverley A. Orser and John F. MacDonald},
  journal={Nature Neuroscience},
  year={2000},
  volume={3},
  pages={559-565}
}
In central neurons, the second messenger cGMP is believed to induce long-term changes in efficacy at glutamatergic synapses through activation of protein kinase G (PKG). Stimulating nitric oxide synthase, activating soluble guanylyl cyclase or elevating concentrations of intracellular cGMP depressed excitatory synaptic transmission in CA1 hippocampal neurons. Unexpectedly, intracellular cGMP depressed responses of AMPA receptors and inhibited excitatory postsynaptic currents in hippocampal… CONTINUE READING
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