Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle*

  title={Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle*},
  author={Vincent Sauzeau and Hélène Le Jeune and Chrystelle Cario-Toumaniantz and Albert Smolenski and Suzanne M. Lohmann and Jacques Bertoglio and Pierre Chardin and Pierre Pacaud and Gervaise Loirand},
  journal={The Journal of Biological Chemistry},
  pages={21722 - 21729}
The potent vasodilator action of cyclic GMP-dependent protein kinase (cGK) involves decreasing the Ca2+ sensitivity of contraction of smooth muscle via stimulation of myosin light chain phosphatase through unknown mechanisms (Wu, X., Somlyo, A. V., and Somlyo, A. P. (1996)Biochem. Biophys. Res. Commun. 220, 658–663). Myosin light chain phosphatase activity is controlled by the small GTPase RhoA and its target Rho kinase. Here we demonstrate cGMP effects mediated by cGK that inhibit RhoA… 

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