Cyclic GMP contact points within the 63-kDa subunit and a 240-kDa associated protein of retinal rod cGMP-activated channels.

@article{Brown1995CyclicGC,
  title={Cyclic GMP contact points within the 63-kDa subunit and a 240-kDa associated protein of retinal rod cGMP-activated channels.},
  author={Randi L Brown and Robert E Gramling and Robert J Bert and Jeffrey W. Karpen},
  journal={Biochemistry},
  year={1995},
  volume={34 26},
  pages={8365-70}
}
Ion channels from retinal rods and a variety of other cells are directly gated by cyclic nucleotides. The rod channel is known to contain a 63-kDa subunit, and there is molecular genetic evidence for the existence, in human retina, of a second subunit with a deduced molecular mass of about 100 kDa. When purified from bovine rods, the channel consists of the 63-kDa subunit and a 240-kDa associated protein that has been shown recently to contain a version of the cloned second subunit as part of a… CONTINUE READING

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