Cyclic GMP as the mediator of molsidomine-induced vasodilatation.

  title={Cyclic GMP as the mediator of molsidomine-induced vasodilatation.},
  author={Walter R. Kukovetz and Sigrid Holzmann},
  journal={European journal of pharmacology},
  volume={122 1},
The mode of action of the in vitro active metabolites SIN-1 and SIN-1A of the vasodilator prodrug molsidomine was studied in bovine coronary artery strips. Both compounds increased cyclic GMP levels in close association with, but prior to their relaxing action. Relaxation and rises in cyclic GMP by SIN-1 were potentiated by M & B 22,948, an inhibitor of… CONTINUE READING