Cyclic GMP and calcium: The internal messengers of excitation and adaptation in vertebrate photoreceptors

@article{Pugh1990CyclicGA,
  title={Cyclic GMP and calcium: The internal messengers of excitation and adaptation in vertebrate photoreceptors},
  author={E. Pugh and T. Lamb},
  journal={Vision Research},
  year={1990},
  volume={30},
  pages={1923-1948}
}
  • E. Pugh, T. Lamb
  • Published 1990
  • Psychology, Medicine
  • Vision Research
  • The roles of cyclic GMP (cGMP) and calcium (Ca2+) in vertebrate rod phototransduction are reviewed, with the emphasis on developments since the discovery of the cGMP-activated conductance of the rod outer segment. The first hypothesis subjected to critical examination is that cGMP acts as the sole internal messenger of excitation. This hypothesis is evaluated with a formal, quantitative model of the biochemical actions of cGMP. Application of the model shows a remarkable agreement between… CONTINUE READING

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