Cyclic-GMP-Binding, Cyclic-GMP-Specific Phosphodiesterase (PDE5) Gene Expression Is Regulated during Rat Pulmonary Development

Abstract

Increased nitric oxide (NO) production plays a critical role in the mammalian pulmonary vascular adaptation to extrauterine life. NO activates soluble guanylate cyclase, increasing intracellular cGMP concentrations, thereby inducing relaxation of vascular smooth muscle. cGMP is inactivated by cyclic nucleotide phosphodiesterases (PDEs). One PDE isozyme… (More)
DOI: 10.1203/00006450-199802000-00002

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