Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

@article{Sun2013CyclicGS,
  title={Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.},
  author={Lijun Sun and Jiaxi Wu and Fenghe Du and Xiang Chen and Zhijian J Chen},
  journal={Science},
  year={2013},
  volume={339 6121},
  pages={786-91}
}
The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the… CONTINUE READING
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