Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms
@article{Grsoy2017CyclicDI, title={Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms}, author={Ulvi Kahraman G{\"u}rsoy and Mervi G{\"u}rsoy and Eija K{\"o}n{\"o}nen and Herman O. Sintim}, journal={Frontiers in Cellular and Infection Microbiology}, year={2017}, volume={7} }
Oral cavity acts as a reservoir of bacterial pathogens for systemic infections and several oral microorganisms have been linked to systemic diseases. Quorum sensing and cyclic dinucleotides, two “decision-making” signaling systems, communicate to regulate physiological process in bacteria. Discovery of cyclic dinucleotides has a long history, but the progress in our understanding of how cyclic dinucleotides regulate bacterial lifestyle is relatively new. Oral microorganisms form some of the…
Figures from this paper
12 Citations
Signaling Systems in Oral Bacteria.
- BiologyAdvances in experimental medicine and biology
- 2019
The supra- and subgingival plaque biofilm communities of plaque are composed of hundreds of different microbes and can be a well-organized polymicrobial community that remains in homeostasis with the host, or a dysbiotic community that provokes pathogenic responses in the host.
Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?
- Biology, MedicinePathogens
- 2021
This review focuses on the possible role of bacterial cyclic dinucleotides and the STING/TBK1/IRF3 pathway in the pathogenesis of periodontal disease and the regulation ofperiodontal immune response, and review and discuss activators and inhibitors of the STing pathway as immune response regulators and their potential utility in the treatment of periodentitis.
Metatranscriptomic analysis of an in vitro biofilm model reveals strain-specific interactions among multiple bacterial species
- BiologyJournal of oral microbiology
- 2019
The existence of strain-specific interactions in subgingival plaque may enhance the understanding of periodontal micro-ecology and facilitate the development of improved plaque control strategies.
Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides
- Biology, MedicineJournal of oral microbiology
- 2019
ABSTRACT Background: Cyclic dinucleotides (cyclic di-guanosine monophosphate (c-di-GMP) and cyclic di-adenosine monophosphate (c-di-AMP)) and lipopolysaccharides (LPS) are pathogen-associated…
Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide
- Biology, MedicinePathogens
- 2020
Evidence is produced that cyclic dinucleotides interact with LPS-mediated early response of gingival fibroblasts, while late cellular response is mainly regulated by LPS.
Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP
- BiologyJournal of Oral Microbiology
- 2021
This study has added to the increasing appreciation that beyond the regulation of cytokine production via STING, cyclic dinucleotides also broadly affect many critical processes in human cells.
The Function of the Oral Microbiome in Health and Disease
- Biology, Medicine
- 2020
The current knowledge on the function that oral microbes play in health and disease is summarized and the role of members of the oral microbiome in systemic diseases, including cardiovascular disease, cancer, and adverse pregnancy outcomes is described.
Global Proteomic Analyses of STING‐Positive and ‐Negative Macrophages Reveal STING and Non‐STING Differentially Regulated Cellular and Molecular Pathways
- BiologyProteomics. Clinical applications
- 2020
To identify macrophage proteins that are affected by STING, a global perspective of how the presence or lack of STING affect the proteome is lacking is lacking.
The oralome and its dysbiosis: New insights into oral microbiome-host interactions
- BiologyComputational and structural biotechnology journal
- 2021
References
SHOWING 1-10 OF 40 REFERENCES
Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development
- BiologyBiofouling
- 2014
The results of an in silico pharmacophore-based screen to identify small-molecule inhibitors of diguanylate cyclase (DGC) enzymes that synthesize c-di-GMP are described, representing the first compounds identified from an insilico screen that are able to inhibit DGC activity to prevent biofilm formation.
Identification of Small Molecules That Antagonize Diguanylate Cyclase Enzymes To Inhibit Biofilm Formation
- BiologyAntimicrobial Agents and Chemotherapy
- 2012
Seven small molecules that antagonize these enzymes and inhibit biofilm formation by Vibrio cholerae are reported, representing the first compounds described that are able to inhibit DGC activity to prevent biofilm Formation.
Biofilms as “Connectors” for Oral and Systems Medicine: A New Opportunity for Biomarkers, Molecular Targets, and Bacterial Eradication
- Biology, MedicineOmics : a journal of integrative biology
- 2016
New directions for both oral and systems medicine are suggested, using various omics technologies such as SILAC and RNAseq, that could yield deeper insights, biomarkers, and molecular targets to design small molecules that selectively aim at eradication of pathogenic oral bacteria.
Identification of a Diguanylate Cyclase and Its Role in Porphyromonas gingivalis Virulence
- BiologyInfection and Immunity
- 2014
Evidence is provided that the PGN_1932 protein is both responsible for synthesizing c-di-GMP and involved in biofilm formation and host cell invasion by P. gingivalis by controlling the expression and biosynthesis of FimA.
Biofilm switch and immune response determinants at early stages of infection.
- BiologyTrends in microbiology
- 2013
Regulation of oxidative response and extracellular polysaccharide synthesis by a diadenylate cyclase in Streptococcus mutans.
- BiologyEnvironmental microbiology
- 2016
The results reported here show that CdaA is an important global modulator in S. mutans and is required for optimal growth and environmental adaption and paves the way to unveil further the roles of c-di-AMP signalling networks in the biology and pathogenicity of S. Mutans.
A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2005
The data suggest that the wsp signal transduction pathway regulates biofilm formation through modulation of cyclic diguanylate levels.
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
- BiologyMicrobiology and Molecular Reviews
- 2013
A historic perspective on the development of the field is provided, common trends are emphasized, and new directions in c-di-GMP research are highlighted that will give a deeper understanding of this truly universal bacterial second messenger.
c-di-GMP (3′-5′-Cyclic Diguanylic Acid) Inhibits Staphylococcus aureus Cell-Cell Interactions and Biofilm Formation
- BiologyAntimicrobial Agents and Chemotherapy
- 2005
It is proposed that cyclic dinucleotides such as c-di-GMP, used either alone or in combination with other antimicrobial agents, represent a novel and attractive approach in the development of intervention strategies for the prevention of biofilms and the control and treatment of infection.
Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2002
The genome analysis provides further insight into how S. mutans has adapted to surviving the oral environment through resource acquisition, defense against host factors, and use of gene products that maintain its niche against microbial competitors.