Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.

Abstract

Signaling via the intracellular second messenger cyclic AMP (cAMP) has long been implicated in the repression of megakaryocytic differentiation. However, the mechanisms by which cAMP signaling impairs megakaryopoiesis have never been elucidated. In a human CD34(+) cell culture model, we show that the adenylyl cyclase agonist forskolin inhibits… (More)
DOI: 10.1074/jbc.M112.366476

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Cite this paper

@article{Rubinstein2012CyclicAS, title={Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.}, author={Jeremy D Rubinstein and Kamaleldin E. Elagib and Adam N. Goldfarb}, journal={The Journal of biological chemistry}, year={2012}, volume={287 23}, pages={19207-15} }