Cyclic AMP reverses radiocontrast media-induced apoptosis in LLC-PK1 cells by activating A kinase/PI3 kinase.

@article{Yano2003CyclicAR,
  title={Cyclic AMP reverses radiocontrast media-induced apoptosis in LLC-PK1 cells by activating A kinase/PI3 kinase.},
  author={Takahisa Yano and Yoshinori Itoh and Toshiaki Sendo and Toshio Kubota and Ryozo Oishi},
  journal={Kidney international},
  year={2003},
  volume={64 6},
  pages={2052-63}
}
BACKGROUND Radiographic contrast material is one of agents that are prone to cause nephropathy, although little is known about cellular mechanisms underlying contrast media-induced renal failure. The present study was designed to determine the role of caspase in contrast media-induced renal injury. The modulation by cyclic adenosine monophosphate (cAMP) of cell injury was subsequently examined. METHODS LLC-PK1 cells (a proximal renal tubular cell line of porcine origin) were exposed to… CONTINUE READING
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