Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.

@article{Lee1990CyclicAMPresponsiveTA,
  title={Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.},
  author={Cathy Q. Lee and Y D Yun and James P. Hoeffler and Joel Francis Habener},
  journal={The EMBO journal},
  year={1990},
  volume={9 13},
  pages={4455-65}
}
Cyclic AMP-regulated gene expression is mediated by specific phosphoproteins (CREBs) which bind to cAMP-responsive elements of gene promoters. By analyzing the transactivation activities and phosphorylations in vivo of deletion and point mutated chimeric fusion proteins of the placental CREB-327, in which the DNA-binding domain is replaced by the heterologous binding-domain of the yeast transcription factor GAL4, we localized the cAMP-responsive and phosphorylated domain to a minimal-essential… CONTINUE READING
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