Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA.

@article{Hoeffler1988CyclicAD,
  title={Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA.},
  author={James P. Hoeffler and Terrance E. Meyer and Y D Yun and Jacqueline Jameson and Joel Francis Habener},
  journal={Science},
  year={1988},
  volume={242 4884},
  pages={1430-3}
}
Cyclic AMP (cAMP) is an intracellular second messenger that activates transcription of many cellular genes. A palindromic consensus DNA sequence, TGACGTCA, functions as a cAMP-responsive transcriptional enhancer (CRE). The CRE binds a cellular protein of 38 kD in placental JEG-3 cells. A placental lambda gt11 library was screened for expression of specific… CONTINUE READING