Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus.

@article{Pandey2007CyclicAR,
  title={Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus.},
  author={G. N. Pandey and Yogesh Dwivedi and Xinguo Ren and Hooriyah S. Rizavi and Rosalinda C. Roberts and Robert R. Conley},
  journal={The international journal of neuropsychopharmacology},
  year={2007},
  volume={10 5},
  pages={621-9}
}
Abnormalities in both adenylyl cyclase (AC) and phosphoinositide (PI) signalling systems have been observed in the post-mortem brain of suicide victims. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is activated by phosphorylating enzymes such as protein kinase A (PKA) and protein kinase C (PKC), which suggests that both AC and PI signalling systems converge at the level of CREB. CREB is involved in the transcription of many neuronally expressed genes that… CONTINUE READING
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Abnormal expression and functional characteristics of cyclic AMP response element binding protein (CREB) in postmortem brain of suicide subjects

  • Y Dwivedi, J SridharaRao, +5 authors GN Pandey
  • Archives of General
  • 2003
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