Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer.

@article{Seo2008CyclicAR,
  title={Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer.},
  author={Hyobin Seo and Diane D. Liu and Benjamin Nebiyou Bekele and Mi-kyoung Kim and Katherine M. W. Pisters and Scott Michael Lippman and Ignacio Wistuba and Ja Seok Koo},
  journal={Cancer research},
  year={2008},
  volume={68 15},
  pages={
          6065-73
        }
}
Lung cancer is the leading cause of cancer deaths worldwide. Recent advances in targeted therapies hold promise for the development of new treatments for certain subsets of cancer patients by targeting specific signaling molecule. Based on the identification of the transcription factor cyclic AMP response element-binding protein (CREB) as an important regulator of growth of several types of cancers and our recent findings of its importance in normal differentiation of bronchial epithelial cells… CONTINUE READING
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