Cyclic AMP receptor protein-dependent activation of the Escherichia coli acsP2 promoter by a synergistic class III mechanism.

@article{Beatty2003CyclicAR,
  title={Cyclic AMP receptor protein-dependent activation of the Escherichia coli acsP2 promoter by a synergistic class III mechanism.},
  author={Christine M. Beatty and Douglas F Browning and Stephen J W Busby and Alan J Wolfe},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 17},
  pages={5148-57}
}
The cyclic AMP receptor protein (CRP) activates transcription of the Escherichia coli acs gene, which encodes an acetate-scavenging enzyme required for fitness during periods of carbon starvation. Two promoters direct transcription of acs, the distal acsP1 and the proximal acsP2. In this study, we demonstrated that acsP2 can function as the major promoter and showed by in vitro studies that CRP facilitates transcription by "focusing" RNA polymerase to acsP2. We proposed that CRP activates… CONTINUE READING