Cyclic AMP phosphodiesterases of human and rat islets of Langerhans: contributions of types III and IV to the modulation of insulin secretion.

@article{Parker1995CyclicAP,
  title={Cyclic AMP phosphodiesterases of human and rat islets of Langerhans: contributions of types III and IV to the modulation of insulin secretion.},
  author={Janice C Parker and Maria A Vanvolkenburg and Robert J Ketchum and K L Brayman and Kim M. Andrews},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={217 3},
  pages={916-23}
}
This study evaluated the contribution of isozymes of cAMP phosphodiesterase (PDE) to total PDE activity in human and rat islets using type-selective inhibitors. The effects of selected PDE inhibitors on insulin secretion from human and rat islets were also measured in order to assess the contribution of the various PDE isozymes to the modulation of insulin secretion. The data suggest that PDE III is quantitatively the most important PDE isozyme present in islets, accounting for up to 70% of the… CONTINUE READING