Cyclic AMP metabolism in fragile X syndrome.

  title={Cyclic AMP metabolism in fragile X syndrome.},
  author={Elizabeth M. Berry-Kravis and Peter R. Huttenlocher},
  journal={Annals of neurology},
  volume={31 1},
Cyclic AMP (cAMP) metabolism was studied in platelets from a series of 14 patients with fragile X syndrome (fra X) and 21 control individuals. 1-Isobutyl-3-methylxanthine was used to inhibit phosphodiesterase and thus measure cAMP production, prostaglandin E1 was used to assess receptor-mediated cAMP accumulation, and forskolin was used to directly stimulate the catalytic subunit. In patients with fra X, basal production was 63% of that of control subjects (p = 0.019). Prostaglandin E1- and… CONTINUE READING

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