Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP.

@article{Tsuruta1995CyclicAI,
  title={Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP.},
  author={Lisako Tsuruta and Hyun Jun Lee and Esteban S. Masuda and Naoko Koyano-Nakagawa and Naoko Arai and Ken-ichi Arai and Takashi Yokota},
  journal={Journal of immunology},
  year={1995},
  volume={154 10},
  pages={5255-64}
}
cAMP inhibits PMA-induced IL-2 production at the transcriptional level in EL-4, a mouse lymphoma line. The region of the mouse IL-2 promoter covering positions from -321 to +46 relative to the transcription initiation site is required for activation by PMA and inhibition by cAMP. This region contains the nuclear factor of activated T cells (NF-AT), nuclear factor-kappa B (NF-kappa B), AP-1, and Oct binding sites, and the role of each element in responding to PMA and/or cAMP signals was… CONTINUE READING