Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21.

@article{Hayashi2000CyclicAI,
  title={Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21.},
  author={Shigeoki Hayashi and Ryuichi Morishita and Hiromichi Matsushita and Hironori Nakagami and Yoshiaki Taniyama and Toshikazu Nakamura and Motokuni Aoki and Kei Yamamoto and Jitsuo Higaki and Toshio Ogihara},
  journal={Hypertension},
  year={2000},
  volume={35 1 Pt 2},
  pages={237-43}
}
Although cAMP is an important second messenger that plays a pivotal role in the regulation of platelet aggregation and dilatation of blood vessels, little is known about the action of cAMP on the growth of vascular smooth muscle cells (VSMCs). Thus, we initially studied the effects of cAMP accumulation by using various cAMP stimulants, including a phosphodiesterase type 3 inhibitor (cilostazol) on human aortic VSMC growth. Accumulation of cAMP inhibited the platelet-derived growth factor (PDGF… CONTINUE READING

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Endothelial cell motility, integrin receptor clustering, and microfilament orga242 Hypertension

  • MG Lampugnani, M Giorgi, M Gaboli, E Dejana, PC. Marchisio
  • Part II by guest on February
  • 2000

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