Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways.

@article{Ishizaki2003CyclicAI,
  title={Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways.},
  author={Tsutomu Ishizaki and Hideki Chiba and Takashi Kojima and Masato Fujibe and Tamotsu Soma and Hideaki Miyajima and Kunihiko Nagasawa and Ikuo Wada and Norimasa Sawada},
  journal={Experimental cell research},
  year={2003},
  volume={290 2},
  pages={275-88}
}
Cyclic AMP (cAMP) promotes functions of tight junctions in endothelial cells, although its target remains unknown. We showed here that cAMP increased gene expression of claudin-5 and decreased that of claudin-1 in porcine blood-brain-barrier endothelial cells via protein kinase A (PKA)-independent and -dependent pathways, respectively. cAMP also enhanced immunoreactivity of claudin-5 along cell borders and in the cytoplasm, reorganized actin filaments, and altered signals of claudin-5, occludin… CONTINUE READING
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